As a teenager, Elizabeth Webber was part of a tight foursome that included Emily Quartermaine, Lucky Spencer, and Lucky's half-brother Nikolas Cassadine (Tyler Christopher). The group remained close over the years, especially after they paired up with each other romantically.

In 2009, when Liz was divorced from Lucky and Nik was grieving Emily's death, the two began sleeping together in secret (via Soaps). Eventually, Elizabeth and Lucky reconciled, and Nikolas dated and got engaged to Emily's long-lost twin Rebecca Shaw. However, Liz and Nik couldn't deny their chemistry and continued having an affair. When Nikolas broke down after discovering that Rebecca was only using him to get to his fortune and admitting that he was using her to replace Emily, he and Elizabeth slept together one final time. Unfortunately, Lucky happened to walk in on them, and the betrayal was enough to end his relationship with Liz for good. 

Soon after, Elizabeth discovered she was pregnant with her third son, Aiden, but didn't know whether Lucky or Nikolas was the father. Eventually, a DNA test showed Nik was the baby daddy, and he helped raise the boy for a year before Aiden's resemblance to Lucky urged Elizabeth to run another test. This time, it proved that Lucky was the biological father, and the family later learned that Helena Cassadine had tampered with the original results.