Rey Mysterio celebrated his 20th anniversary with WWE in July 2022, and it's a testament to his longevity that he still has the hunger and desire to compete at the highest level. Of course, Mysterio has had his fair share of injuries with knee problems and bicep issues among others.

RELATED: Rey Mysterio's 10 Worst Matches, According To Cagematch.net

Mysterio has maximized his potential which has led him to become a three-time WWE World Champion and he was the winner of the 2006 Royal Rumble match. The Master of the 619 has mixed it up with the very best in the business, and he has participated in several marquee matches in WWE, and respected wrestling journalist Dave Meltzer has picked out the best of a very good bunch.

12 Men's Royal Rumble Match - Royal Rumble 2021 (4.25 Stars)

Rey Mysterio was the number 26 entrant in his 12th Royal Rumble match in 2021. Mysterio was seeking his Rumble victory, and he drew a very good number. However, Mysterio was virtually non-existent in this Rumble.

AJ Styles' bodyguard Omos wasn't an official participant, but that did not deter him in the slightest from getting involved physically. Omos eliminated Mysterio and Big E, and Mysterio only managed to get three minutes under his belt.

11 Men's Royal Rumble Match - Royal Rumble 2020 (4.25 Stars)

The WWE Champion Brock Lesnar was on a rampage in the men's 2020 Royal Rumble match, and he showed no signs of letting up. Rey Mysterio entered the Rumble as the seventh participant, and he worked alongside Kofi Kingston and Big E in a bid to stop Lesnar's dominance.

Mysterio only lasted two minutes and 54 seconds which was bitterly disappointing. Moreover, since Lesnar was on a rampage, there wasn't much that Mysterio could do, and he was one of Lesnar's 13 victims.

10 Rey Mysterio Vs. Andrade - SmackDown 1/15/19 (4.25 Stars)

Rey Mysterio and Andrade clashed once more on the January 15, 2019 edition of SmackDown. There's no surprise that Mysterio and Andrade had a barnburner of a wrestling match that was pay-per-view quality.

RELATED: 10 Best Rey Mysterio Action Figures, Ranked

The match went back and forth, and there were several near falls. Mysterio went to the top rope but Andrade knocked him off it, and he connected with a DDT for the win with his manager Zelina Vega distracting the referee.

9 Rey Mysterio Vs. Eddie Guerrero - SmackDown 11/14/02 (4.25 Stars)

Fans are guaranteed to witness good matches every time Rey Mysterio and Eddie Guerrero lock horns. On the November 14, 2002 taping of SmackDown, they went toe-to-toe with both men looking to take some momentum into Survivor Series.

Mysterio's tag partner Edge and Eddie's nephew Chavo were banned from ringside, but that did not stop them from getting involved when the referee was knocked down. Mysterio gave it his best shot, but Guerrero prevailed with the Lasso from El Paso.

8 Men's Royal Rumble Match - Royal Rumble 2018 (4.25 Stars)

Rey Mysterio marked his return to WWE as a surprise entrant in the men's 2018 Royal Rumble match, and he drew the most successful number to garner the most Rumble winners, the coveted 27th position. Mysterio was still in great shape and he had a good outing.

The Ultimate Underdog lasted just under 10 minutes, and he was one of the final six competitors in the Rumble. Mysterio eliminated Adam Cole which was his sole elimination, but his quest for a second Rumble win was ended by Finn Balor.

7 Rey Mysterio Vs. Kane Vs. Edge Vs. Alberto Del Rio - TLC 2010 (4.25 Stars)

Rey Mysterio was seeking his third World Heavyweight Championship reign at TLC 2010. However, he had to do it the hard way in a TLC match against the defending champion Kane, Edge, and Alberto Del Rio in a fatal-4-way match.

RELATED: Every WWE PPV Main Event From 2010, Ranked Worst To Best

The action momentarily spilled onto the outside, and they battled at the top of the stage. Nonetheless, Mysterio and Edge clashed at the top of the ladder, but they both crashed and burned. Ultimately, the Rated-R Superstar captured his 10th World Championship and the emotion poured out afterward.

6 Rey Mysterio Vs. Edge Vs. Kane Vs. Drew McIntyre Vs. Big Show Vs. Wade Barrett - Elimination Chamber 2011 (4.25 Stars)

Huge implications heading into WrestleMania 27 were at stake with Rey Mysterio challenging Edge for the World Heavyweight Championship in an Elimination Chamber match with Kane, Drew McIntyre, Big Show, and Wade Barrett as the other challengers. Mysterio had to go the distance if he was going to prevail as he began proceedings with Edge.

Mysterio and Edge were the final two, and their battle was nothing short of extraordinary. Edge connected with a spear but Mysterio kicked out, and Edge kicked out of Mysterio's Splash. Edge had another trick up his sleeve as he connected with a Spear in mid-air in a successful title defense.

5 Rey Mysterio Vs. John Morrison - SmackDown 9/4/09 (4.25 Stars)

Rey Mysterio and John Morrison battled in one of the greatest Intercontinental Championship matches to take place on SmackDown. Both men don't shy away from going airborne, and they had some good exchanges throughout.

Mysterio had his chances to put the Guru of Greatness but Morrison held firm. Nevertheless, Morrison connected with Starship Pain and that was enough for him to clinch his third Intercontinental Championship reign.

4 Rey Mysterio Vs. Kurt Angle - SmackDown 6/2/06 (4.25 Stars)

Rey Mysterio's World Heavyweight Championship was not on the line in Kurt Angle's final match on SmackDown before he jumped ship to ECW. Their chemistry together was magnificent, which is why their matches were captivating to watch.

RELATED: Kurt Angle's Wrestling Career Told In Photos, Through The Years

The Olympic Gold Medalist was in his Wrestling Machine mode, and he was the aggressor throughout. Mysterio was sent to the outside of the ring by Angle, and he was unable to make it back at the count of 10 with Angle signing off SmackDown with a win.

3 Rey Mysterio Vs. John Cena Vs. Edge Vs. Kane Vs. Mike Knox Vs. Chris Jericho - No Way Out 2009 (4.25 Stars)

The Elimination Chamber match for John Cena's World Heavyweight Championship was nothing short of extraordinary. Mysterio, Kane, Mike Knox, Chris Jericho, and Edge who replaced Kofi Kingston were Big Match John's challengers.

Mysterio had a remarkable outing and he started the match with Jericho. Mysterio registered the first elimination as he got rid of the Devil's Favorite Demon. Mysterio also eliminated Jericho, and he was left to slug it out with Edge. The former WWE Tag Team Champions went back and forth, but Edge launched Mysterio into a pod, and he connected with a spear and a ninth World Championship reign came his way.

2 Rey Mysterio Vs. Seth Rollins Vs. Finn Balor Vs. Kevin Owens - Raw 10/25/21 (4.5 Stars)

Rey Mysterio, Seth Rollins, Finn Balor, and Kevin Owens slugged it out in a fatal-4-way ladder match with the winner going on to become the number one contender for Big E's WWE Championship. All four men had reached the mountain top before, and they're looking to do it once more.

The action was off the charts, and Mysterio executed a seated senton on the outside. Mysterio came close to reaching the contract, but he was knocked off the ladder. The Visionary prevailed after the coast was clear in a hard-fought battle.

1 Rey Mysterio Vs. Chris Jericho - The Bash 2009 (4.5 Stars)

Rey Mysterio was looking to regain the Intercontinental Championship from Chris Jericho at The Bash 2009. However, Mysterio's mask was on the line in this high-stakes match. Nevertheless, Mysterio and Jericho stole the show in a magnificent wrestling match.

Mysterio had a lot of offense, and this was a fast-paced match. Y2J attempted to rip Mysterio's mask off, but Mysterio had the last laugh as he had another mask on. Jericho was confused, which allowed Mysterio to take advantage and he recaptured the Intercontinental Championship.