Per Soap Dirt, at the Boronsky clinic in St. Petersburg, Russia, Ava Jerome was taken in by the doctors who claimed to be able to reconstruct her face with an experimental procedure. There, she encountered a captive man known only as Patient 6 and was warned he was dangerous. Influenced by the fact that Griffin encouraged her to do more good than misdeeds, Ava helped Patient 6 escape. However, the doctors had nefarious plans for him and were enraged when he absconded. 

Meanwhile, Griffin Munro had researched the supposed procedure that would fix Ava, and, suspecting that it wasn't on the level, he went after her. The doctors threatened Ava, but Griffin managed to show up just in time to rescue her. Back in Port Charles, Griffin used notes he acquired at the clinic to supervise the restoration of Ava's face, according to Michael Fairman TV. 

Ava had drawn the wrath of Nikolas Cassadine's young son, Spencer Cassadine (then Nicholas Bechtel), because she protected Valentin Cassadine from the accusations that he killed Nikolas. She also started to combat Sonny Corinthos over custody of their daughter Avery. As Ava's misdeeds started to pile up again, her relationship with the good Griffin was severely strained, per Celeb Dirty Laundry.

Ava eventually dumped him, so Griffin then started an affair with Kiki Jerome. When Ava found out, she went ballistic, seeking revenge against both of them.