According to Bill Hader, their time together at NBC, as well as filming "The Skeleton Twins," made him realize how much Kristen Wiig meant to him. "Making this movie I was like, 'Oh yeah, Kristen, you're like a huge part of my life'," he said during an appearance on AOL's Build series, adding that Wiig said the same about him. Hader also described "The Skeleton Twins" as one of his best filming experiences` and called his co-star one of the best actors in the industry.

Hader explained to ABC's film critic Peter Travers how they both "work very much in the same way" and "immediately picked up" their chemistry from SNL for their first co-starring roles in "Adventureland" (via YouTube). In the 2009 film, they play a married couple who also own the theme park that the movie revolves around (via YouTube).

While their performances in "Adventureland" are hilarious, it's their poignant and believable relationship as brother and sister in "The Skeleton Twins" that helped to establish them outside the sphere of "Saturday Night Live." As Wiig told the New York Times, "Doing a movie by myself, people just assume it's a comedy. With Bill and me, I knew people would be quick to think it's a comedy, which makes sense" (via Miami Herald). "But to really appreciate the movie," she added, "you have to go in with an open mind, because we've got some dramatic stuff in there as well."