Due to Spencer Breslin's seamless chemistry with Dakota Fanning in "The Cat in the Hat," it's easy to mistake the two for being siblings in real life. While that is untrue, Spencer, like his fictional counterpart, does have a younger sister who is just as precocious as Sally. Thanks to the massive success of her older brother, Abigail Breslin found her way into show business at the age of three. By 2002, she'd go on to work with the likes of Mel Gibson and Joaquin Phoenix in "Signs." As each of their popularity grew, it was only a matter of time before the two would cross paths with one another.

In 2004, the two made their on-screen debut together in "Raising Helen," where they played Henry and Sarah Davis. Judging from their appearances on different media outlets like Jay Leno's talk show, it was clear their rapport, albeit childish, was infectious. This caused directors to go all-in with the brother and sister duo, casting them in films like "Princess Diaries 2: Royal Engagement" and "The Santa Clause 3: The Escape Clause." 

Though Abigail eventually parted ways with Spencer, finding success through films like "Little Miss Sunshine" and "Zombieland," Spencer appeared on Elle Mills' podcast to recall the fond memories he had working with his little sister. When asked if working with Abigail was annoying, he replied: "Yeah, kind of. Like I remember telling her she was being unprofessional, a bunch of stuff like that."