Sisters Gwen (Nadine Nicole) and Emma Randall (Alice Greczyn) discovered that neurologist Dr. Simon Neville had lost his medical license and was fired from the hospital where he worked for using unconventional methods, per Soaps. At the time, Neil Winters (Kristoff St. John) had been keeping his comatose ex-wife, Hilary Hamilton (Mishael Morgan), in his boathouse. Gwen contacted Simon, asking him to use one of his experimental drugs to help Hilary. He did so, and while monitoring her care, he fell asleep. Hilary awoke from her coma, fleeing the boathouse. Simon eventually located her, and after knocking her out with drugs, he and Gwen secretly brought Hilary to a hospital, leaving her in a random bed.

Later, Simon snuck into the hospital disguised as a flower delivery guy to check out Hilary's medical charts. He then handed Gwen some meds, instructing her to give them to Hilary. Finding a delirious Hilary wandering about later, Dylan McAvoy (Steve Burton) figured out Simon's medicine was dangerous. He went to her hotel room, where Simon jumped him, knocked him out, and escaped (via Soap Central).

Then, Ashley Abbott (Eileen Davidson) wanted to sell the cure that Simon had used on Hilary. She set him up with a laboratory, and Devon Hamilton (Bryton James) financed the project. As they got closer, Simon realized Ashley was ailing, and she confessed to having had an aneurysm and brain tumor. Simon was determined to cure her.